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1

Mitochondrial Function, Biology, and Role in Disease

Murphy, Elizabeth, Ardehali, Hossein, Balaban, Robert S., DiLisa, Fabio, Dorn, Gerald W., Kitsis, Richard N., Otsu, Kinya, Ping, Peipei, Rizzuto, Rosario, Sack, Michael N., Wallace, Douglas, Youle, Ri

Journal:

Circulation Research

Année:

2016

Langue:

english

Fichier:

PDF, 908 KB

english, 2016

2

Role of Autophagy in Aging

Yamaguchi, Osamu, Otsu, Kinya

Journal:

Journal of Cardiovascular Pharmacology

Année:

2012

Langue:

english

Fichier:

PDF, 163 KB

english, 2012

3

Involvement of p38 in Age-Related Decline in Adult Neurogenesis via Modulation of Wnt Signaling

Kase, Yoshitaka, Otsu, Kinya, Shimazaki, Takuya, Okano, Hideyuki

Journal:

Stem Cell Reports

Année:

2019

Langue:

english

Fichier:

PDF, 4.38 MB

english, 2019

4

Influence of clinical and genetic factors on warfarin dose requirements among Japanese patients

Masako Ohno, Akiko Yamamoto, Ayumu Ono, Genta Miura, Masanobu Funamoto, Yasuhiko Takemoto, Kinya Otsu, Yasushi Kouno, Tomoko Tanabe, Yuiko Masunaga, Shinpei Nonen, Yasushi Fujio, Junichi Azuma

Journal:

European Journal of Clinical Pharmacology

Année:

2009

Langue:

english

Fichier:

PDF, 147 KB

english, 2009

5

Acrolein, an Environmental Toxin, Induces Cardiomyocyte Apoptosis via Elevated Intracellular Calcium and Free Radicals

Lijuan Wang, Yingxian Sun, Michio Asahi, Kinya Otsu

Journal:

Cell Biochemistry and Biophysics

Année:

2011

Langue:

english

Fichier:

PDF, 259 KB

english, 2011

6

Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

Nakagawa, Takashi, Shimizu, Shigeomi, Watanabe, Tetsuya, Yamaguchi, Osamu, Otsu, Kinya, Yamagata, Hirotaka, Inohara, Hidenori, Kubo, Takeshi, Tsujimoto, Yoshihide

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 625 KB

english, 2005

7

Discovery of Atg5/Atg7-independent alternative macroautophagy

Nishida, Yuya, Arakawa, Satoko, Fujitani, Kenji, Yamaguchi, Hirofumi, Mizuta, Takeshi, Kanaseki, Toku, Komatsu, Masaaki, Otsu, Kinya, Tsujimoto, Yoshihide, Shimizu, Shigeomi

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 1018 KB

english, 2009

8

The kinase p38α serves cell type–specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression

Kim, Chun, Sano, Yasuyo, Todorova, Kristina, Carlson, Bradley A, Arpa, Luis, Celada, Antonio, Lawrence, Toby, Otsu, Kinya, Brissette, Janice L, Arthur, J Simon C

Journal:

Nature Immunology

Année:

2008

Langue:

english

Fichier:

PDF, 794 KB

english, 2008

9

Monophosphoryl lipid A provides biphasic cardioprotection against ischaemia-reperfusion injury in rat hearts

Nobushige Yamashita, Shiro Hoshida, Kinya Otsu, Naoyuki Taniguchi, Tsunehiko Kuzuya, Masatsugu Hori

Journal:

British Journal of Pharmacology

Année:

1999

Langue:

english

Fichier:

PDF, 307 KB

english, 1999

10

The involvement of cytokines in the second window of ischaemic preconditioning

Nobushige Yamashita, Shiro Hoshida, Kinya Otsu, Naoyuki Taniguchi, Tsunehiko Kuzuya, Masatsugu Hori

Journal:

British Journal of Pharmacology

Année:

2000

Langue:

english

Fichier:

PDF, 290 KB

english, 2000

11

Pathological neoangiogenesis depends on oxidative stress regulation by ATM

Okuno, Yuji, Nakamura-Ishizu, Ayako, Otsu, Kinya, Suda, Toshio, Kubota, Yoshiaki

Journal:

Nature Medicine

Année:

2012

Langue:

english

Fichier:

PDF, 5.02 MB

english, 2012

12

Usefulness of High-Resolution Real-Time Three-Dimensional Echocardiography to Visualize the Left Ventricular Endocardial Surface in Myocardial Infarction

Koichi Inoue, Hiroshi Ito, Katsuomi Iwakura, Shigeo Kawano, Atsunori Okamura, Toshiya Kurotobi, Motoo Date, Kinya Otsu, Masatsugu Hori, Kenshi Fujii

Journal:

The American Journal of Cardiology

Année:

2006

Langue:

english

Fichier:

PDF, 606 KB

english, 2006

13

Single-strand conformation polymorphism analysis on the δ-sarcoglycan gene in Japanese patients with hypertrophic cardiomyopathy

Moto-o Date, Kinya Otsu, Kazuhiko Nishida, Toshihiko Toyofuku, Yasushi Matsumura, Takashi Morita, Shinichi Hirotani, Yasushi Okazaki, Yoshihide Hayashizaki, Vincenzo Nigro, Tsunehiko Kuzuya, Michihiko

Journal:

The American Journal of Cardiology

Année:

2000

Langue:

english

Fichier:

PDF, 92 KB

english, 2000

14

Regulation of Sarco(endo)plasmic Reticulum Ca2+ Adenosine Triphosphatase by Phospholamban and Sarcolipin: Implication for Cardiac Hypertrophy and Failure

Michio Asahi, Hiroyuki Nakayama, Michihiko Tada, Kinya Otsu

Journal:

Trends in Cardiovascular Medicine

Année:

2003

Langue:

english

Fichier:

PDF, 575 KB

english, 2003

15

Involvement of NF-Y in transcriptional regulation of the phospholamban gene

Masanori Yabuki, Toshihiko Toyofuku, Kinya Otsu, Masashi Nishida, Tsunehiko Kuzuya, Masatsugu Hori, Michihiko Tada

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 312 KB

english, 1998

16

Cloning and Characterization of the 5′-Upstream Regulatory Region of the Ca2+-Release Channel Gene of Cardiac Sarcoplasmic Reticulum

Kazuhiko Ntshida, Kinya Otsu, Masatsugu Hori, Tsunehiko Kuzuya, Michihiko Tada

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 1.21 MB

english, 1996

17

Chromosome Mapping of Five Human Cardiac and Skeletal Muscle Sarcoplasmic Reticulum Protein Genes

Kinya Otsu, Junichi Fujii, Muthu Periasamy, Michael Difilippantonio, Madhvi Uppender, David C. Ward, David H. MacLennan

Journal:

Année:

1993

Fichier:

PDF, 333 KB

1993

18

Thyroid Hormone Enhances Ca2+ Pumping Activity of the Cardiac Sarcoplasmic Reticulum by Increasing Ca2+ ATPase and Decreasing Phospholamban Expression

Yoshihiro Kimura, Kinya Otsu, Kazuhiko Nishida, Tsunehiko Kuzuya, Michihiko Tada

Journal:

Journal of Molecular and Cellular Cardiology

Année:

1994

Fichier:

PDF, 553 KB

1994

19

Intracellular Calcium Level Required for Calpain Activation in a Single Myocardial Cell

Yasushi Matsumura, Eijiro Saeki, Kinya Otsu, Takashi Morita, Hiroshi Takeda, Tsunehiko Kuzuya, Masatsugu Hori, Hideo Kusuoka

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2001

Langue:

english

Fichier:

PDF, 166 KB

english, 2001

20

Involvement of Reactive Oxygen Species-mediated NF- κ B Activation in TNF- α -induced Cardiomyocyte Hypertrophy

Yoshiharu Higuchi, Kinya Otsu, Kazuhiko Nishida, Shinichi Hirotani, Hiroyuki Nakayama, Osamu Yamaguchi, Yasushi Matsumura, Hikaru Ueno, Michihiko Tada, Masatsugu Hori

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2002

Langue:

english

Fichier:

PDF, 210 KB

english, 2002

21

Regulation of sarcoplasmic reticulum gene expression in human heart failure

Masashi Arai, Kinya Otsu, David H MacLennan, Norman R Alpert, Paul Barton, Muthu Periasamy

Journal:

Journal of Molecular and Cellular Cardiology

Année:

1992

Langue:

english

Fichier:

PDF, 100 KB

english, 1992

22

Apoptosis signal-regulating kinase 1 is involved not only in apoptosis but also in non-apoptotic cardiomyocyte death

Tetsuya Watanabe, Kinya Otsu, Toshihiro Takeda, Osamu Yamaguchi, Shungo Hikoso, Kazunori Kashiwase, Yoshiharu Higuchi, Masayuki Taniike, Atsuko Nakai, Yasushi Matsumura, Kazuhiko Nishida, Hidenori Ich

Journal:

Biochemical and Biophysical Research Communications

Année:

2005

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2005

23

Ca2+ Content and Ca2+ Leakage at a Steady State are not Influenced by Genetic Modulation of Ca2+ Uptake Rate in SR

Satoshi Morimoto, Makoto Kawai, Jin O-Uchi, Kimiaki Komukai, Kenichi Hongo, Toshihiro Takeda, Kinya Otsu, Satoshi Kurihara

Journal:

Journal of Cardiac Failure

Année:

2007

Langue:

english

Fichier:

PDF, 51 KB

english, 2007

24

Activated cardiac steroidogenesis and increased glucocorticoid promote cardiac hypertrophy

Tomohito Ohtani, Toshiaki Mano, Shungo Hikoso, Yasushi Sakata, Yasuharu Takeda, Kinya Otsu, Kazuhiro Yamamoto

Journal:

Journal of Cardiac Failure

Année:

2008

Langue:

english

Fichier:

PDF, 47 KB

english, 2008

25

Downregulation of ferritin heavy chain increases labile iron pool, oxidative stress and cell death in cardiomyocytes

Shigemiki Omiya, Shungo Hikoso, Kinya Otsu

Journal:

Journal of Cardiac Failure

Année:

2008

Langue:

english

Fichier:

PDF, 49 KB

english, 2008

26

Essential Role of Autophagy to Maintain Cardiac Function in Response to Hemodynamic Stress and in Senescence

Osamu Yamaguchi, Kinya Otsu

Journal:

Journal of Cardiac Failure

Année:

2010

Langue:

english

Fichier:

PDF, 35 KB

english, 2010

27

Signaling Pathways and Genes that Inhibit Pathogen-Induced Macrophage Apoptosis— CREB and NF-κB as Key Regulators

Jin Mo Park, Florian R. Greten, Athena Wong, Randal J. Westrick, J. Simon C. Arthur, Kinya Otsu, Alexander Hoffmann, Marc Montminy, Michael Karin

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 730 KB

english, 2005

28

Autophagy in cardiomyocyte is essential for maintenance of cardiac function and response to external stress

Atsuko Nakai, Kinya Otsu, Osamu Yamaguchi, Noboru Mizushima, Masatsugu Hori

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2006

Langue:

english

Fichier:

PDF, 57 KB

english, 2006

29

Autophagy in cardiomyocyte is essential for maintenance of cardiac function and response to external stress

Shungo Hikoso, Atsuko Nakai, Osamu Yamaguchi, Noboru Mizushima, Kinya Otsu, Masatsugu Hori

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2007

Langue:

english

Fichier:

PDF, 47 KB

english, 2007

30

Reduction of hemoglobin-oxygen affinity improves exercise capacity in mice with chronic heart failure

Shungo Hikoso, Tetsuya Watanabe, Kinya Otsu, Masatsugu Hori

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2007

Langue:

english

Fichier:

PDF, 59 KB

english, 2007

31

Cell death and cardiac remodeling

Osamu Yamaguchi, Toshihiro Takeda, Yoshihide Tsujimoto, Kinya Otsu

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2008

Langue:

english

Fichier:

PDF, 45 KB

english, 2008

32

Downregulation of ferritin heavy chain increases labile iron pool, oxidative stress and cell death in cardimyocytes

Shigemiki Omiya, Shungo Hikoso, Kinya Otsu

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2008

Langue:

english

Fichier:

PDF, 50 KB

english, 2008

33

Cardiac Steroidogenesis and Glucocorticoid Contribute to Augmentation of Cardiac Hypertrophy

Tomohito Ohtani, Toshiaki Mano, Shungo Hikoso, Yasushi Sakata, Yasuharu Takeda, Kinya Otsu, Masatsugu Hori, Kazuhiro Yamamoto

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2008

Langue:

english

Fichier:

PDF, 64 KB

english, 2008

34

The role of IKKβ/NF-κB pathway in the pathogenesis of heart failure

Shungo Hikoso, Kinya Otsu, Masatsugu Hori

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2008

Langue:

english

Fichier:

PDF, 64 KB

english, 2008

35

Reduction in Hemoglobin-Oxygen Affinity Results in the Improvement of Exercise Capacity in Mice with Chronic Heart Failure

Toshihiro Takeda, Tetsuya Watanebe, Shigemiki Omiya, Kinya Otsu

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2008

Langue:

english

Fichier:

PDF, 59 KB

english, 2008

36

Activation of MTK1/MEKK4 induces cardiomyocyte death and heart failure

Isamu Mizote, Osamu Yamaguchi, Shungo Hikoso, Toshihiro Takeda, Manabu Taneike, Takafumi Oka, Takahito Tamai, Jota Oyabu, Yasushi Matsumura, Kazuhiko Nishida, Issei Komuro, Masatsugu Hori, Kinya Otsu

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2010

Langue:

english

Fichier:

PDF, 1.22 MB

english, 2010

37

Disruption of a single copy of the p38α MAP kinase gene leads to cardioprotection against ischemia–reperfusion

Kinya Otsu, Nobushige Yamashita, Kazuhiko Nishida, Shinichi Hirotani, Osamu Yamaguchi, Tetsuya Watanabe, Shungo Hikoso, Yoshiharu Higuchi, Yasushi Matsumura, Masumi Maruyama, Tatsuhiko Sudo, Hiroyuki

Journal:

Biochemical and Biophysical Research Communications

Année:

2003

Langue:

english

Fichier:

PDF, 194 KB

english, 2003

38

S3-2 Role of manganese superoxide dismutase in late phase preconditioning

Kinya Otsu, Nobushige Yamashita, Shiro Hoshida, Masatsugu Hori

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2002

Langue:

english

Fichier:

PDF, 194 KB

english, 2002

39

Molecular bases for malignant hyperthermia

Journal:

Neuroscience Research

Année:

1998

Langue:

english

Fichier:

PDF, 101 KB

english, 1998

40

Ca2+/calmodulin-dependent protein kinase II activates apoptosis signal-regulating kinase 1 and nuclear factor-kappaB to induce cardiomyocyte hypertrophy

Kashiwase Kazunori, Otsu Kinya, Yamaguchi Osamu, Hikoso Syungo, Takeda Toshihiro, Watanabe Tetsuya, Taniike Masayuki, Asahi Michio, Nishida Kazuhiko, Hori Masatsugu

Journal:

Journal of Cardiac Failure

Année:

2004

Langue:

english

Fichier:

PDF, 49 KB

english, 2004

41

Roles of Mitogen-activated Protein Kinase Signaling Pathway in Cardiac Remodeling

Journal:

Journal of Cardiac Failure

Année:

2005

Langue:

english

Fichier:

PDF, 6 KB

english, 2005

42

Apoptosis Signal-regulating Kinase 1 is Involved Not Only in Apoptosis But Also in Non-apoptotic Cardiomyocyte Death

Tetsuya Watanabe, Kinya Otsu, Masatsugu Hori

Journal:

Journal of Cardiac Failure

Année:

2005

Langue:

english

Fichier:

PDF, 17 KB

english, 2005

43

Chronic Inhibition of Apoptosis Signal-regulating Kinase 1 (ASK-1) by Myocardial Gene Transfer Suppressed Progression of Heart Failure in Genetic Cardiomyopathy

Yasuhiro Ikeda, Shungo Hikosou, Osamu Yamaguchi, Toshihiro Takeda, Kazunori Kashiwase, Shinichi Hirotani, Michio Yamada, Kinya Otsu, Masunori Matsuzaki, Masatsugu Hori

Journal:

Journal of Cardiac Failure

Année:

2005

Langue:

english

Fichier:

PDF, 20 KB

english, 2005

44

Gab Family Docking Proteins are Essential for Prevention of Dilated Cardiomyopathy through Transmitting Neuregulin-ErbB Signaling

Yoshikazu Nakaoka, Keigo Nishida, Atsunori Kamiya, Hirofumi Sawa, Kinya Otsu, Hisao Hirota, Toshio Hirano, Naoki Mochizuki

Journal:

Journal of Cardiac Failure

Année:

2006

Langue:

english

Fichier:

PDF, 57 KB

english, 2006

45

Relationship between effects of statins, aspirin and angiotensin II modulators on high-sensitive C-reactive protein levels

Toshihiro Takeda, Shiro Hoshida, Masami Nishino, Jun Tanouchi, Kinya Otsu, Masatsugu Hori

Journal:

Atherosclerosis

Année:

2003

Langue:

english

Fichier:

PDF, 163 KB

english, 2003

46

The antioxidant N-2-mercaptopropionyl glycine attenuates left ventricular hypertrophy in in vivo murine pressure-overload model

Moto-o Date, Takashi Morita, Nobushige Yamashita, Kazuhiko Nishida, Osamu Yamaguchi, Yoshiharu Higuchi, Shinichi Hirotani, Yasushi Matsumura, Masatsugu Hori, Michihiko Tada, Kinya Otsu

Journal:

Journal of the American College of Cardiology

Année:

2002

Langue:

english

Fichier:

PDF, 227 KB

english, 2002

47

Repeated physiologic stresses provide persistent cardioprotection against ischemia-reperfusion injury in rats

Shiro Hoshida, Nobushige Yamashita, Kinya Otsu, Masatsugu Hori

Journal:

Journal of the American College of Cardiology

Année:

2002

Langue:

english

Fichier:

PDF, 199 KB

english, 2002

48

Functional role of c-Src on gap junction in cardiomyopathic heart

Toshihiko Toyofuku, Masanori Yabuki, Kinya Otsu, Masashi Nishida, Tsunehiko Kuzuya, Michihiko Tada, Masatsugu Hori

Journal:

Journal of Cardiac Failure

Année:

1999

Langue:

english

Fichier:

PDF, 115 KB

english, 1999

49

S3-3 Cardiomyocyte Death and Heart Failure

Journal:

CVD Prevention and Control

Année:

2009

Langue:

english

Fichier:

PDF, 52 KB

english, 2009

50

Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation

Huang, Gonghua, Wang, Yanyan, Vogel, Peter, Kanneganti, Thirumala-Devi, Otsu, Kinya, Chi, Hongbo

Journal:

Nature Immunology

Année:

2012

Langue:

english

Fichier:

PDF, 6.02 MB

english, 2012